FABRICATION AND CHARACTERIZATION OF BREAST PHANTOM BASED ON GELATIN-GLYCERIN-TiO2 FOR A CONTINUOUS-WAVE DIFFUSE OPTICAL TOMOGRAPHY
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Published:
Nov 30, 2019
Keywords:
Breast phantom gelatin glycerin titanium dioxide optical tomograph
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Abstract
In this paper, the fabrication and characterization of breast phantom based on gelatin-glycerin-TiO2 as breast simulation tissue is proposed and investigated. A sample preparation was done by mixing 3 grams of gelatin per 10 ml of saline. The sample was added with glycerin with four different concentrations of 85%, 90%, 95% and 100% as sample A, B, C and D respectively. The sample D is optimum as it was able to survive at room temperature for 126 hours. Subsequently, sample D was added by TiO2 given variations of 0.010 grams, 0.015 grams, 0.020 grams and 0.025 grams. All samples were tested for its homogeneity and absorption coefficient using Continuous Wave Diffuse Optical Tomography (CW-DOT) with laser wavelengths of 780, 808 and 830 nm. The results showed that the optimum sample characterization was achieved at wavelength of 830 nm with TiO2 variation of 0.025 grams. The absorption coefficient breast phantom was obtained at 0.167 mm-1. Phantom based on gelatin-glycerin-TiO2 can be applied as material replacement of breast for test object in CW-DOT.
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Ukhrowiyah, N., Hikmawat, D., Yasin, M., & Yuni, R. (2019). FABRICATION AND CHARACTERIZATION OF BREAST PHANTOM BASED ON GELATIN-GLYCERIN-TiO2 FOR A CONTINUOUS-WAVE DIFFUSE OPTICAL TOMOGRAPHY. Malaysian Journal of Science, 38(Sp3), 53–65. https://doi.org/10.22452/mjs.sp2019no3.6
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UMInd2018 (Published)
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De Grand A.M., Lomnes S.J., Lee D.S., et al. (2006) Tissue-like phantoms for near-infrared fluorescence imaging system assessment and the training of surgeons, J. Biomed Opt. 2006;11(1):014007.
Heilscher, A.H, A.Y. Bluestone, G.S. Abdoulaev, A.D. Klose, J. Lasker, M. Stewart, U. Netz, dan J. Beuthan (2002) Near-infrared diffuse optical tomography, Disease Markers, 18 (313-337).
Jiang, S., Pogue, B.W., Mc. Bride, T.O., Paulsen, K.D. (2003) Quantitative analysis of near-infrared tomography: sensitivity to the tissue-simulating precalibration phantom, J. Biomed Opt. 8 (2), 308-315.
Kemsley E. Kate, Henri S. Tapp, Richard Binns, Robert O. Mackin, Anthony J. Peyton (2008) Feasibility study of NIR diffuse optical tomography on agricultural produce, Journal of Postharvest Biology and technology 48223-230.
Lualdi M., Colombo A., Farina B. and Tomatis S., Marchesini R. ( 2001) A phantom with tissue-like optical properties in the visible and near infrared for use in photomedicine, Lasers in Surgery and Medicine Vol. 28.
McKee, C. T. (2011), Indentation Versus Tensile Measurements of Young’s Modulus for Soft Biological Tissues, Tissue Engineering, Part B Volume 17.
N. Ukhrowiyah, D. Kurniadi, Suhariningsih, M. Yasin (2015) Continuous Wave Diffuse Optical Tomography Using Multimode Plastic Fiber for Non-destructive Test of Diffused Material, Optoelectronic and Advanced Material-Rapid Communication,Vol. 9, No. 7-8, p. 995 - 999
Pogue, B.W. and M.S. Patterson (2006) Review of tissue simulating phantoms for optical spectroscopy, imaging and dosimetry, J Biomed Opt. 11(4): p. 041102.
Riset Kesehatan Dasar (2013) Badan Penelitian dan Pengembangan Kesehatan, Kementrian Kesehatan RI, p 38.